Phytochemicals in Cancer Prevention and Therapy.

Cancer therapy with phytochemicals: evidence from clinical studies

Cancer is still one of the major causes of mortality in both developing and developed countries. At this time, in spite of intensive interventions, a large number of patients have poor prognosis. Therefore, the effort for finding new anticancer agents with better efficacy and lesser side effects has continued. According to the traditional recommendations and experimental studies, numerous medic...

Phytochemicals and Cancer – Possible Molecular Targets of Phytochemicals in Cancer Prevention and Therapy

Molecular targets of pomegranate (Punica granatum) in preventing cancer metastasis

Metastasis is the primary cause of mortality and morbidity among cancer patients and accounts for about 90% of cancer deaths. The most common types of treatment for cancer metastasis are chemotherapy and radiotherapy. However, such therapy has many serious side effects that could diminish the quality of life in patients. There is increased appreciation by the scientific community that natural c...

Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy

Despite the advances in biomedical research and clinical applications, cancer remains a leading cause of death worldwide. Given the limitations of conventional chemotherapeutics, including serious toxicities and reduced quality of life for patients, the development of safe and efficacious alternatives with known mechanism of action is much needed. Prevention of cancer through dietary interventi...

Phytochemicals for breast cancer prevention by targeting aromatase.

Aromatase is a cytochrome P450 enzyme (CYP19) and is the rate limiting enzyme in the conversion of androgens to estrogens. Suppression of in situ estrogen production through aromatase inhibition is the current treatment strategy for hormone-responsive breast cancers. Drugs that inhibit aromatase have been developed and are currently utilized as adjuvant therapy for breast cancer in post-menopau...

اثرات ضد سرطانی رزوراترول بر سرطان پستان

Breast cancer is the most common cancer in women worldwide. Current cancer treatments have multiple side effects, including damage to healthy cells, drug resistance and disease recurrence. Therefore, new therapeutic strategies are needed to achieve fewer toxicity and side effects. Several studies suggest that phytochemicals could be considered as appropriate choices for cancer prevention and...